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FH wrote the manuscript with proofreading by FM. Final approval was given by all authors. Received: 1 July 2014 Accepted: 4 July4.5. Work in the Helmbacher laboratory was supported by funds from the CNRS (ATIP grant), FRM (Fondation pour la Recherche M icale, Equipe FRM 2007), AFM (Association Fran ise contre les Myopathies), FdF (Fondation de France), ARC (Association pour la Recherche contre le Cancer) and ANR (Agence Nationale de la Recherche, ANR Neuro 2007).15.9. Acknowledgements We thank Chris Henderson for invaluable intellectual support; Ruediger Klein for supporting this study in its early stages and for valuable comments on the manuscript, and former members of his laboratory for insightful discussion;